Infliximab

• What is infliximab?

  Anti-TNF agent
• What is the phamacology of infliximab?

  Target: TNF-a

  Action: Antagonist
• MOA - Infliximab

  Binds to TNF-a -> stops TNF-a from interacting with receptors ->

  • decreases local & systemic pro-inflammatory cytokines
  • decreased lymphocyte & leukocyte migration to sites of inflammation
  • induces apoptosis of TNF producing cells
  • decreases endothelial adhesion molecules
  • decreases acute-phase proteins
• What are the indications of infliximab?

  Crohn's

  Ulcerative colitis

  Rheumatoid arthritis
• What are the side effects of infliximab?

  Anaemia

  Diarrhoea

  Nausea