Psychoactive substances may either imitate natural chemical messengers involved in relaying signals in the brain or overstimulate or inhibit certain parts of the brain.
The most recent criteria for substance use disorders dropped the term addiction because substance use disorders have a wide range of symptoms, from mild to severe.
Substance use disorders are a group of disorders characterized by mental, behavioral, and bodily symptoms that result from a person's continued use of a substance despite it causing significant substance-related problems.
Intoxication is a substance-specific syndrome which includes body and behavioral changes that are observed due to the recent intake of a substance or drug.
Withdrawal is a substance-specific syndrome which includes body and behavioral changes that are observed due to stopping or reduction of heavy and prolonged substance use.
Methamphetamine affects the brain by inducing the production of more dopamine, which is the chemical signal for the reward and pleasure centers of the brain.