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• What are the primary storage sites for serotonin?

  Enterochromaffin cells and platelets
• What is one of the central nervous system effects of serotonin?

  Mood regulation
• How does serotonin affect blood pressure?

  It regulates blood pressure
• What role does serotonin play in temperature regulation?

  It helps regulate body temperature
• How does serotonin influence pain perception?

  It acts as a stimulant for pain perception
• What is one of the peripheral effects of serotonin?

  Vasoconstriction
• What are the types of serotonin receptors?

  1. 5HT1A
  2. 5HT1B/1D
  3. 5HT2A
  4. 5HT2C
  5. 5HT3
  6. 5HT4

  
• Where is the 5HT1A receptor located?

  CNS in presynapse of neurons
• What effect does the 5HT1A receptor have on serotonin release?

  It decreases the release of serotonin
• What is the coupling type of the 5HT1B/1D receptor?

  Gi coupled
• Where is the 5HT1B/1D receptor located?

  Peripheral smooth muscles
• What effect does the 5HT1B/1D receptor have?

  It causes contraction
• What is the coupling type of the 5HT2A receptor?

  Gq coupled
• What effect does the 5HT2A receptor have?

  It causes vasoconstriction
• Where is the 5HT2C receptor located?

  CNS
• What effect does the 5HT2C receptor have?

  It reduces appetite
• What type of channel is the 5HT3A receptor?

  Ligand gated ion channel
• Where is the 5HT3A receptor located?

  Area of postrema of CTZ
• What effect does the 5HT3A receptor have?

  It induces vomiting
• What is the coupling type of the 5HT4 receptor?

  Gs coupled
• Where is the 5HT4 receptor located?

  GIT
• What effect does the 5HT4 receptor have?

  It promotes peristalsis
• What are the uses of 5HT1A receptor drugs?

  • Partial agonist in the brain
  • Used as an anti-depressant
  • Example: Buspirone (BuSpar)
• What are the uses of 5HT1B/1D receptor drugs?

  • Agonists for acute migraine and cluster headache
  • Examples: Sumatriptan, Naratriptan, Zolmitriptan
• What is the prototype drug for 5HT1B/1D receptor?

  Sumatriptan
• What is the duration of action for Sumatriptan?

  2-3 hours
• How is Sumatriptan metabolized?

  By MAOA
• What are the side effects of 5HT1B/1D receptor drugs?

  Coronary vasospasm and paresthesias
• What are the uses of 5HT2A receptor drugs?

  • Partial agonists for acute migraine and cluster headache
  • Examples: Ergotamine, Dihydroergotamine (DHE)
• What is the best route for Ergotamine administration?

  Rectal
• What is the risk associated with ergots?

  Rebound headache
• What is the effect of Dexfenfluramine?

  Reduces appetite for weight control
• What are the uses of 5HT3 receptor antagonists?

  • Management of chemotherapy-induced nausea and vomiting (CINV)
  • Examples: Ondansetron, Granisetron
• What is the route for Palonosetron administration?

  Single IV dose for 5-7 days
• What are the uses of 5HT4 receptor drugs?

  • Management of Irritable Bowel Syndrome (IBS) and GERD
  • Examples: Tegaserod, Cisapride
• What are eicosanoids?

  • Important group of endogenous fatty acids
  • Synthesized from arachidonic acid
• What are the sites affected by eicosanoids?

  1. Vascular smooth muscles
  2. Bronchial smooth muscles
  3. Platelets
  4. Cytoprotection (stomach mucus production)
  5. Uterus (uterine contraction)
  6. Eyes (intraocular pressure)
• What is the effect of PGI2 and PGE1?

  They cause vasodilation
• What is the effect of TXA2 and PGF2?

  They cause vasoconstriction
• What is the effect of PGI2 and PGF2alpha?

  They cause bronchodilation