Bone Healing

• What are the 4 stages of bone healing?

  Haemostasis

  Inflammation

  Proliferation

  Maturation/Remodelling
• What is in the haemostasis stage of bone healing?

  Haematoma formation
• What is in the inflammatory stage of bone healing?

  Vasodilation & increased vascular permeability

  Influx of inflammatory cells

  Formation of granulation tissue

  Osteoprogenitor cells recruited to site
• What is in the proliferation stage of bone healing?

  Soft callus formation - bridges fracture ends & stabilise bone

  Chondrocytes lay down cartilage & supporting blood vessels into callus

  Soft cartilaginous callus is reabsorbed & replaced by hard callus (woven bone)

  Cartilage matrix is calcified & resorbed & replaced w/woven bone -> increased mechanical rigidity
• What is in the maturation/remodelling stage of bone healing?

  Hard callus resorbed & remodelled into lamellar bone

  Osteoclasts resorb woven bone

  Osteoblasts deposit new lamellar bone