Tissue Healing

Cards (6)

  • Why do contractures occur in wound healing relating to amputation?
    Problem with recontraction
    If full ROM is not initiated in early stages after amputation -> develops contractures
    Abnormal shortening of muscle tissue = muscle highly resistant to stretching
    Fibrosis of tissues supporting muscle or joint
  • What are the factors that influence tissue repair?
    Infection
    Smoking
    Immunosuppression
    Age
    Chronic conditions
    Hypoxia
    Wound management
  • What are the 4 stages of tissue healing?
    Haemostasis
    Inflammation
    Proliferation
    Remodelling
  • What happens in haemostasis?
    Vasoconstriction
    Formation of platelet plug
  • What in inflammation stage of tissue repair?
    Early stage
    • local vasodilation
    • recruitment of inflammatory cells
    Late stage
    • resolution of inflammation
    • macrophages M1 -> M2
    • production of anti-inflammatory cytokines & growth factors
  • What happens in the proliferative stage of tissue healing?
    Angiogenesis
    Formation of granulation tissue
    Re-epithelialisation
    Wound contraction