The neural explanation of schizophrenia looks at correlations among the brain structures of people with schizophrenia.
Enlarged ventricles: Several studies have found correlations between enlarged ventricles in the brain and schizophrenia. For example, Johnstone et al (1976) and Suddath et al (1990). Enlargedventricles are particularly linked with the negative symptoms of schizophrenia, as shown in studies such as Andreasen et al (1982).
Reduced grey matter and cortical thinning: Boos et al (2012) compared MRI scans of 155 schizophrenic patients, 186 non-schizophrenicfamily members, and 122 non-schizophrenic controls. The researchers found that the schizophrenic patients had reduced grey matter and cortical thinning compared to their non-schizophrenic family members and the non-schizophrenic controls. This further supports the existence of a neural basis for schizophrenia.
