Renal Physiology

• Cannot give NSAIDs with ACEi.
• What molecules are ONLY reabsorbed in PCT via channels?

  Glucose

  Amino acids

  Phosphate
• What ion in reabsorbed w/o a channel in the PCT?

  Bicarbonate
• What ions are reabsorbed in LoH?

  Na+ (via NKCC & paracellularly)

  K+ (via NKCC)

  Cl- (via NKCC)

  Ca+2 (paracellular)

  Mg+2 (paracellular)
• What are the potential causes of a raised anion gap metabolic acidosis?

  MUDPILES

  Methanol

  Uraemia

  DKA (inc. SGLT2i)

  Paracetamol

  Isoniazid

  Lactate (inc. metformin)

  Ethylene glycol (anti-freeze)

  Salicylates (aspirin)