Krebs Cycle

• The Krebs cycle involves a series of oxidative-reduction reactions, which take place in the matrix of the mitochondria. The cycle happens once for every pyruvate molecule, so it goes around twice for every glucose molecule.
• Stage One

  • The acetyle group from acetyl CoA combines with oxaloacetate to from citrate. This is catalysed by citrate synthatse.
  • Coenzyme A goes back to the link reaction to be used again.
• Stage Two

  • The 6C citrate molecule is converted to a 5C molecule as decarboxylation occurs and Co2 is removed.
  • Dehydrogenation also occurs, where hydrogen is removed. This hydorgen is used to produce NADH from NAD.