QUIZ 5- LEUKOCYTE DISORDER

• Which disorder results from a mutation in the STAT3 gene?

  • Job’s
• What does the term myelokathexis refer to?

  • Neutrophil accumulation in the bone marrow
• All of the following describe Alder-Reilly anomaly, EXCEPT:

  • Presence of Döhle bodies
• Which of the following are RNA remnants?

  • Tart cells
• A condition characterized by an increased white blood cell (WBC) count is called:

  • Leukocytosis
• What can cause basophilia?

  • Two of the above
  • Allergies
  • Recovery from neutropenia
• Which condition occurs exclusively in female patients?

  • Barr body
• Overproduction of plasma cells is characteristic of:

  • Myeloma
• According to WHO, the criteria for diagnosing acute myeloid leukemia (AML) require a blast percentage of:

  • ≥20%
• Which FAB classification is associated with proliferation of erythroid cells?

  • FAB M6
• The most common type of leukemia in adults is:

  • Chronic lymphocytic leukemia (CLL)
• Which B-cell neoplasm is associated with the image provided?

  • Hairy cell leukemia
• The Philadelphia chromosome is characterized by which translocation?

  • t(9q;22q)
• All of the following statements regarding primary myelofibrosis are true, EXCEPT:

  • Intramedullary hematopoiesis is impaired
• In which condition is an increased leukocyte alkaline phosphatase (LAP) score observed?

  • Leukemoid reaction
• Which of the following conditions affect LAP results?

  • Hemolytic anemia
• Neutrophils test positive for all of the following stains, EXCEPT:

  • α-Naphthyl Acetate Esterase
• Disseminated intravascular coagulation (DIC) is most commonly associated with:

  • FAB M3
• A punched-out osteoporotic lesion is characteristic of:

  • Multiple myeloma
• All of the following statements regarding chronic myeloid leukemia (CML) are true, EXCEPT:

  • Anemia
• The gamma chain deficiency mutation is located on which chromosome?

  • Xq13.1
• WHIM syndrome is associated with a mutation on which chromosome?

  • 1q42.1-2
• A decrease in nuclear segmentation is seen in:

  • Pelger-Huët anomaly
• The Philadelphia chromosome is associated with which gene?

  • BCR-ABL1
• In polycythemia vera, the mutation occurs in which gene?

  • JAK2