Pharma CNS

• Which of the following is a component of drinking alcohol? A  Ethyl Alcohol

  B  Isopropyl Alcohol

  C Methyl Alcohol

  D  Butyl Alcohol

  Answer A
• What enzyme is primarily responsible for breaking down alcohol in the liver? A  Alcohol Oxidase B  Alcohol Dehydrogenase C Alcohol Kinase D  Alcohol Esterase

  Answer B
• Which neurotransmitter is significantly affected by alcohol, leading to its depressant effects? A  GABA B  Dopamine C Serotonin D  Acetylcholine

  Answer A
• What term describes the phenomenon where regular drinkers require increasing amounts of alcohol to achieve the same effects? A  Tolerance B  Intoxication C Dependency D Withdrawal

  Answer A
• What is the term used to describe the cluster of symptoms that occur when a person dependent on alcohol suddenly stops drinking? A  Delirium Tremens B  Hangover C  Alcohol Poisoning D  Inebriation Syndrome

  Answer A
• Sarah, a 27-year-old woman, has been a social drinker for several years. Recently, she has noticed that she needs more alcohol to achieve the same level of intoxication she used to experience with smaller amounts. Concerned about her increasing tolerance, she decides to learn more about alcohol pharmacology. Sarah experiences withdrawal symptoms when she attempts to cut down on alcohol. Which neurotransmitter system is primarily implicated in these withdrawal symptoms? A  Serotonergic system B  Dopaminergic system C  GABAergic system D  Glutamatergic system

  Answer C
• Long-term excessive alcohol consumption can result in a decrease in the activity of which specific neurotransmitter, contributing to cognitive deficits and addiction-related behaviors? A  Norepinephrine B  Acetylcholine C  Glutamate

  D Dopamine

  Answer B
• What is the primary mechanism of action of benzodiazepines in the central nervous system? A  Block GABA receptor B  Enhance dopamine release C  Inhibit serotonin reuptake D  Increase acetycholine levels

  Answer A
•  Which alternative class of medications, primarily used for anxiety, targets serotonin receptors? A  Barbiturates B Benzodiazepine C Selective Serotonin Reuptake Inhibitors D Monoamine Oxidase Inhibitors

  Answer C
• Which medication acts by binding selectively to the BZ1 receptor subtype of the GABA-A receptor complex, inducing sleep in individuals with insomnia? A Zolpidem (Ambien) B  Lorazepam (Ativan) C Diazepam (Valium) D  Alprazolam (Xanax)

  Answer A
• Among the listed options, which drug acts by inhibiting the reuptake of dopamine and norepinephrine in the synaptic cleft? A  Rotigotine B Bromocriptine C  Amantadine D Benserazide

  Answer C
• Which anti-Parkinsonism drug, among the choices, is a catechol-O-methyltransferase (COMT) inhibitor used as an adjunct to levodopa therapy? A  Selegiline B  Entacapone C  Tolcapone D  Ropinirole

  Answer C
• Which drug, among the options, functions as a partial dopamine agonist with a high affinity for D3 receptors and is associated with a lower incidence of dyskinesias? A  Entacapone B  Pramipexole C  Amantadine D  Tolcapone

  Answer B
• Which of the following is neuroprotective? A  Levodopa B  Pramiprexole C  Bromocriptine D  Apomorphine

  Answer B
• Which of the following will case Livedo Reticularis? A  Amantadine B  Entacapone C  Selegiline D  Apomorphine

  Answer A
• Which drug, among the listed options, primarily exerts its antiepileptic effects through enhancement of sodium channel inactivation and modulation of calcium channels? A  Zonisamide B  Lamotrigine C  Carbamazepine D  Topiramate

  Answer B
• Among the options, which anti-seizure medication is known to inhibit high-voltage-activated calcium channels and exhibit activity against absence seizures? A  Ethosuximide B  Phenobarbital C  Oxcarbazepine

  D  Valproic acid

  Answer A
• Among the options, which anti-seizure medication primarily modulates the GABA-A receptor complex by increasing the frequency of chloride channel opening without affecting GABA levels? A  Topiramate B  Phenobarbital C  Valproic acid D  Rufinamide

  Answer B
• Among the listed options, which medication primarily inhibits the presynaptic enzyme GABA transaminase, leading to increased GABA levels and enhanced inhibitory neurotransmission? A  Vigabatrin B  Levetiracetam C  Pregabalin D  Gabapentin

  Answer A
• Which anti-seizure drug, among the choices, is a sodium channel blocker primarily used for the treatment of refractory partial seizures and possesses a unique structure containing a triazole ring? A  Rufinamide B  Phenytoin C  Oxcarbazepine D  Lacosamide

  Answer D