epigene

• CpG island methylated phenotype (CIMP) appears in familial colorectal cancer, silencing MCH1, preventing MMR
• IDH, FH or SDH mutations inhibit TET leading to leukemia
• Hypermethylation is a cancer biomarker, specifically GST1 in prostate and SNF in tons of cancer
• Histones can be mutated in cancer themselves, especially in paediatric glioma
• HDACs act as oncogenes