Caspi 5-HTT Gene & Depression

• What was the aim of Caspi et al. (2003) study?

  To investigate gene-environment interaction in depression
• What gene was examined in the Caspi et al. (2003) study?

  The 5-HTT gene
• What type of study was conducted by Caspi et al. (2003)?

  A longitudinal study
• How many participants were involved in the Caspi et al. (2003) study?

  847 participants
• What were the participants assessed for in the study?

  Depression
• What was a key finding of the Caspi et al. (2003) study?

  Short 5-HTT gene version linked to depression
• What are the strengths of the Caspi et al. (2003) study?

  • Large sample increases generalizability
  • Findings relevant to real-life gene-environment interactions
• What are the weaknesses of the Caspi et al. (2003) study?

  • Difficulty in establishing causality
  • Ethical concerns regarding genetic testing