atypical drugs

• However, atypical anti-psychotic drugs only temporarily occupy D2 receptor sites (hit and run binding – rapid dissociation) and allow normal dopamine transmission. These drugs also act on other neurotransmitters so are not directly involved in with just the dopamine system. As a result, atypical drugs carry a lower risk of extrapyramidal effects.
• Atypical antipsychotic drugs have been around since the 1970’s and are sometimes referred to as second-generation antipsychotics. The aim of these drugs is to improve upon the efficacy of typical antipsychotics while reducing side effects.
• Atypical antipsychotics target several neurotransmitters, not just dopamine. For example, clozapine is an atypical antipsychotic that acts on the neurotransmitters dopamine, serotonin, and glutamate. Risperidone, another atypical antipsychotic, targets dopamine and serotonin.
• atypical anti-psychotics side effects

  •Weight gain, sleepiness, low sex drive and may affect blood pressure.
• • Newer drugs, called “atypical antipsychotics” attempt to target D2 dopamine activity in the limbic system but not D3 receptors in other parts of the brain.

  • Atypical antipsychotics such as Clozapine bind to dopamine, serotonin and glutamate receptors.

  • Atypical antipsychotic drugs work on negative symptoms, improving mood, cognitive functions and reducing depression and anxiety.

  • They also have some effect on other neurotransmitters such as serotonin .They generally have fewer side effects eg. less effect on movementEg. Clozapine, Olazapine and Risperidone.