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Analgesics
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Created by
Shawn Mendes
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Cards (10)
There are three types of analgesics
Narcotic analgesics
(
Opioid
analgesics
)
Non-narcotic analgesics
(
Non-steroidal anti-inflammatory drugs
)
Adjuvant analgesics
or
Co-analgesics
mu receptor
sedation; euphoria; inhibition of respiration;
Delta
receptor
modulation of hormone and neurotransmitter release
Kappa receptor
dysphoria; psychotomimetic effects; sedation;
slowed Gl transit
Pure agonists
(primarily at μ, perhaps at k & delta)
morphine
,
hydromorphine
,
oxymorphine
methadone
fentanyl
,
sufentanil
,
alfentanil
,
remifentanil
levorphanol
,
oxycodone
codeine
,
hydrocodone
,
tramadol
(weak μ agonist)
Partial agonist
and
mixed agonist antagonists
butorphanol
nalbuphine
(k agonist, μ antagonist)
pentazocine
(k agonist, weak μ antagonist or partial agonist),
buprenorphine
(partial μ agonist)
Antagonist
(all receptors)
naloxone
,
naltrexone
,
nalmefene
Monoamine oxidase inhibitor
+
Opioid
Hyperpyrexic coma
Hypertension
Sedative hypnotic + Opioid
Increase
CNS depression
Increase
respiratory depression
Antipsychotic agents + Opioid
Sedation
increase
CVS
eff
(
antimuscarinic
and
alpha
blocking action )