IMMUNOSERO - HISTORY

• Edward Jenner - 1700; Vaccination of cowpox against smallpox
• 1885, Louis Pasteur, Reported live attenuated vaccine against rabies
• Antiserum therapy, especially against diptheria - Emil von Behring; 1901
• 1905 - Robert Koch, Tuberculosis
• Paul Erlich - 1908, Theories of Immunity (Cellular and Humoral)
• 1912 - Alexis Carrel; Organ Grafting
• Anaphylaxis - Charles Richet; 1913
• Jules Bordet - Theories of Immunity/Complement; 1919
• Karl Landsteiner - Human Blood Groups; 1930
• Penicillin - 1945

  • Sir Alexander Fleming
  • Sir Ernst Borischain
  • Lord Howard Walter Floray
• Salk and Sabin - Development of Polio Vaccine; 1949
• 1951 - Max Theilier; Yellow Fever Vaccine
• 1952 - Selman Abraham Waksman; streptomycin as first antibiotic against TB
• Daniel Bovet - 1957; Antihistamine Research
• Severo Ochoa & Arthur Komberg - 1959 ; Mechanism of biological synthesis of DNA and RNA
• 1960 - Acquired Immunological Tolerance

  • Sir Frank Macfarlane Burnet
  • Sir Peter Brian Medawar
• 1965 - Genetic Control of Enzymes and Viruses Synthesis

  • Francois Jacob
  • Andrei Lwoff
  • Jacques Monod
• 1966 - Tumor-inducing Virus

  • Payton Rous
• 1968 - Genetic code and its function in protein synthesis

  • Robert Holley
  • Har Gobind Khorana
  • Marshall Nerinberg
• 1969 - Replication Mechanism and Genetics

  • Max Delbruck
  • Alfred Hershey
  • Salvador Luria
• 1972 - Chemical Structure of Immunoglobulin

  • Rodney Porter
  • Geral Edelman
• 1975 - First Monoclonal Antibody

  • Kohler
• 1975 - Interaction tumor viruses and genetic material in cell

  • David Baltimore
  • Renato Dulbeco
  • Howard Martin Ternin
• 1977 - Rosalyn Yellow ; Radioimmunoasay of Peptide Hormones
• 1978 - Molecular Genetics

  • Werner Arber
  • Daniel Nathans
  • Hamilton Smith
• 1980 - Immunogenetics and Histocompatibility

  • Baruj Benacerraf
  • Jean Dausset
  • George Snell
• 1983 - Mobile genetic elements (transposons)

  • Barbara McClintock
• 1984 - Hybridoma Technology/Monoclonal

  • Cesar Milstein
  • George Kohler
  • Niels Jerne
• 1987 - Susumo Tonegawa Immunoglobulin genetics about diversity
• 1989 - Cellular origin of retroviral oncogenes

  • J. Michael Bishop
  • Harold Varmus
• Organ & Cell Transplantation - 1990

  • Joseph Murray
  • E. Donnell Thomas
• 1996 - Specificity of cell-mediated immune defense (dual recognition)

  • Peter Doherty
  • Rolf Zinkemagel
• 1997 - Stanley Prusiner

  Prions as a new biological principle of infection
• 2005 - Frazer ; developmen of human pappiloma virus vaccine
• 1999

  • Gunter Blobel - Signal transduction
• 1999

  • Durham and Gruber - Agglutination
• 1999

  • Graber and Williams - Immunoelectrolhoresis
• 1999

  • Isahizaka - IgE
• 1999

  • Isaacs and Lindenmann - Interferons
• 1999

  • Edward Jnner - Smallpox Vaccine