Phentolamine

• What are the complications of phentolamine?

  Altered HR

  Stroke

  MI

  Severe chest pain

  Loss of consciousness (due to low BP)
• What is phentolamine?

  Non-selective alpha blocker
• What is the pharmacology of phentolamine?

  Target: adrenergic alpha receptors

  Activity: Competitive antagonist
• MOA - phentolamine

  Binds to & inhibits alpha-1 adrenergic receptors → inhibits vasoconstriction that is usually caused by adrenaline binding to alpha-1 receptors → vasodilation → decrease TPR → decrease BP
• What is the indication of phentolamine?

  Hypertensive episodes