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Phentolamine
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Created by
Jessica Jardine
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Cards (5)
What are the complications of phentolamine?
Altered HR
Stroke
MI
Severe chest pain
Loss of consciousness
(due to
low BP
)
What is phentolamine?
Non-selective alpha blocker
What is the pharmacology of phentolamine?
Target:
adrenergic alpha receptors
Activity:
Competitive antagonist
MOA - phentolamine
Binds
to &
inhibits alpha-1 adrenergic receptors
→
inhibits vasoconstriction
that is usually caused by
adrenaline
binding to
alpha-1 receptors
→
vasodilation
→
decrease TPR
→
decrease BP
What is the indication of phentolamine?
Hypertensive episodes