Xavier University was founded in 1933 by Fr James Thomas Gibbons (TG) Hayes SJ.
The initial campus of Xavier University was a two-storey wooden building in Burgos Street with 17 high school male students.
Xavier University experienced rapid expansion in the next 11 years, moving to several buildings in Corrales Street with 614 students.
The College department was added to Xavier University in 1938 with courses in Liberal Arts, Education, and Commerce.
Grade School was established in Xavier University in 1940.
Xavier University was closed on December 9, 1941, due to World War II, and the campus was used by Japanese troops during the war.
The Chemistry Lab at Xavier University was used to extract quinine, a medication to treat malaria and babesiosis.
Xavier University was liberated from Japanese forces, and the campus was bombed by American planes on September 9, 1944, reducing it to rubble.
Reconstruction efforts led to the reopening of Xavier University in 1946 with partially restored buildings.
The Chapel at Xavier University was located at the center of Campion Hall.
Collegiate program offerings at Xavier University expanded to include Bachelor of Arts, Pre-Legal, and Commerce by 1946.
Graduate School opened at Xavier University in 1948, College of Agriculture started in 1953, and College of Law and Manresa Farm in 1955.
In March 1958, two years after Fr Francisco Araneta SJ became Rector, Xavier University was granted university status.
On August 27, 1958, Xavier University-Ateneo de Cagayan was inaugurated as a university, becoming the first university in Mindanao and the first Jesuit University in the Philippines.
The name change to Xavier University merely crystallized the spirit of learning and service, reflecting the soul of all Ateneo schools.
Xavier University expanded courses, becoming a regional education leader.
The 2-year Pre-Engineering (1957) evolved into a 4-year program, opening the College of Engineering (1981).
The Guidance and Counseling course began in 1958 (summer).
College of Medicine started in 1983, Nursing in 1988 (reopened 2002).
Established Center for Industrial Technology (CIT) for technical programs (1983).
The Computer Center started in 1993.
Nursing and Medicine have Maria Reyna - Xavier University Hospital, for the Nursing and Medicine programs in partnership with St Paul of Chartres and the Archdiocese of CDO.
In 2016, XU opened Senior High School (STEM, ABM, HUMSS, & GAS).
The Research Institute for Mindanao Culture (RIMCU) was established in 1957.
University Journal “Kinaadman” started publishing in 1963.
Southeast Asia Rural Social Leadership Institute (SEARSOLIN) started forming and producing rural social development leaders in Asia in 1963.
Philippine Folklife Museum and Archives Museo de Oro; established 1968.
Philippine Folklife Museum and Archives was proposed by Fr Francisco Demetrio SJ., inaugurated by Corazon Aquino.
The Institute for the Development of Educational Administrators (IDEA) Training school administrators since 1972.
May 2014, XU Marine Station in Jasaan, Mis Or was opened under the management and supervision of McKeough Marine Center.
Central to Xavier Education: spiritual, social, psycho-emotional, physical wellness, and sociocultural formation.
Xavier Center for Culture and the Arts launched in 2007 to promote Philippine and Mindanao culture.
Chapel renamed in 2013 as the University Church of the Immaculate Conception in service to the local Church and community.
Programs like First Year Formation and Religious Studies emphasize Jesuit values and community exposures.
Formation units include Campus Ministries, Kristohanong Katilingban sa Pagpakabana (KKP), and Office of Student Affairs.
Operation: Tabang Sendong launched in December 2011 for Typhoon Sendong relief, mobilizing 1,500 volunteers daily, serving 40,000 families, and offering Xavier Ecoville as a resettlement site.
Xavier Ecoville blessed in 2013, envisioned as a community caring for each other, Cagayan de Oro, and the environment.
Xavier University is a product of a rich history and a commitment to address Church, global community, and Filipino people's needs.
Xavier operates on four campuses: Agriculture extension, Center for Integrated Technologies (Manresa), High School and Grade School Annex (Pueblo de Oro), Grade School (Macasandig), and main Tertiary (Corrales Avenue).
Main campus houses colleges of Arts and Sciences, Nursing, Engineering, Agriculture, Computer Studies, Business and Management, Education, Graduate programs, and professional schools of Law and Medicine.