Enalapril

• What is enalapril?

  ACE inhibitor
• What is the pharmacology of enalapril?

  Target: ACE

  Activity: Competitive antagonist
• MOA - enalapril

  Binds to & inhibits ACE -> stops conversion of angiotensin I to angiotensin II -> less angiotensin II -> less vasoconstriction & salt retention in kidneys -> less blood volume & resistance -> decrease CO & TPR -> decrease BP
• What are the indications of enalapril?

  Essential HTN

  Heart failure
• What are the side effects of enalapril?

  Diarrhoea

  Hypotension

  Vomiting