Valsartan

• MOA - valsartan

  Binds to & inhibits angiotensin receptor 1 (AT1) → prevents angiotensin II from binding & exerting its hypertensive effects (vasoconstriction, stimulation & synthesis of aldosterone & ADH, cardiac stimulation, reabsorption of Na+) → reduced BP, lower aldosterone levels, reduced cardiac activity, increased excretion of Na+
• What is valsartan?

  Angiotensin receptor blocker
• What is the pharmacology of valsartan?

  Target: AT1 (receptor)

  Activity: Competitive antagonist
• What are the indications of valsartan?

  Essential HTN

  Heart failure
• What are the side effects of valsartan?

  Diarrhoea

  Nausea

  Vomiting