Amlodipine

Cards (5)

  • MOA - amlodipine
    Acts on vascular smooth muscle, blocks Ca+2 channelsinhibits influx of Ca+2 ions into smooth & cardiac muscle (smooth > cardiac) → decrease contraction (as contraction is Ca+2-dependent) → reduction in peripheral vascular resistancedecrease TPRdecrease BP
  • What is amlodipine?
    Ca+2 channel blocker (dihydropyridine)
  • What is the pharmacology of amlodipine?
    Target: L-type voltage-gated Ca+2 channel
    Activity: Gating inhibitor
  • What are the indications of amlodipine?
    Hypertension
    Angina
  • What are the side effects of amlodipine?
    Abdominal pain
    Nausea
    Vomiting