Amlodipine

• MOA - amlodipine

  Acts on vascular smooth muscle, blocks Ca+2 channels → inhibits influx of Ca+2 ions into smooth & cardiac muscle (smooth > cardiac) → decrease contraction (as contraction is Ca+2-dependent) → reduction in peripheral vascular resistance → decrease TPR → decrease BP
• What is amlodipine?

  Ca+2 channel blocker (dihydropyridine)
• What is the pharmacology of amlodipine?

  Target: L-type voltage-gated Ca+2 channel

  Activity: Gating inhibitor
• What are the indications of amlodipine?

  Hypertension

  Angina
• What are the side effects of amlodipine?

  Abdominal pain

  Nausea

  Vomiting