MiRNA

• MicroRNA genes are initially transcribed by RNA polymerase II as primary microRNA transcripts called pri-miRNA.
• The mature miRNA is incorporated into an Argonaute protein complex known as the RISC complex.
• Pre-miRNAs are exported from the nucleus into the cytoplasm, where they are further processed by Dicer enzymes to produce mature miRNAs.
• Pri-miRNAs undergo processing to form precursor miRNAs (pre-miRNAs) that contain hairpin structures with two single-stranded arms.
• Histone Acetyltransferase
• Epigenetic modifications such as DNA methylation and histone modifications play important roles in regulating gene expression without altering the underlying DNA sequence.
• DNA methylation involves the addition of a methyl group to cytosine residues within CG dinucleotides, which can lead to changes in chromatin structure and gene silencing.
• Histone Modification