Coronaviridae

• has a icoseahderal structure, with a large central core surrounded by a thin layer of cells and a thin layer of connective tissue

  +SSRNA, linear, enveloped with muticlevage sites
• The envelope has spike proteins, membrane glycoproteins, nucleocapsid, and envelope proteins
• has an ORF 1a and 1ab which is 3/4ths of the geome with the rest twards the3' end for streucture and acessory genes
• -1 Ribosomal frame shift?

  is the 3' end of ORF1 that overlaps with the 5' end of ORF1ab so translation tends to terminate and start again but can continue, giving 2 possible fragmented ( like a leaky stop codon)
• pp1a from ORF1a

  pp1ab from ORFb will be cleaved via proteolytic auto processing protease within the protean cleaves it
• NEasted subgenomic RNAs?

  Subgenomic RNAs are smaller RNA molecules that are produced during the replication of certain viruses. They carry specific genetic information and play a role in the virus's life cycle.sub genomes are created by the discontinuous mechanism of translation.
• ExoN-proffreading enzyme allows this RNA virus to be different due to size it allows for more genes including one to proofread.