Anton van Leeuwenhoek was the Father of Microbiology and the first to discover microbes in a fly's eye
Robert Brown was a botanist who discovered the nucleus
Matthias Schleiden hypothesized that a plant cell would grow as an individual unit due to the nucleus
Rudolf Virchow reasoned that every cell comes from preexisting cells
Theodore Schwann discovered that both plants and animals are made up of cells
Unified Cell Theories:
The cell is the basic structural and functional unit of living things
Every organism is made up of cells
Cells come only from preexistingcells
Plasma Membrane:
Thin, outermost membrane that maintains the cell as a distinct entity
Made up of a phospholipid bilayer
3 Basic Components of Cells:
Plasma Membrane or Cell Membrane
Cytoplasm
Nucleus or Nucleoid
Cytoplasm:
Semi-fluid matrix found between the plasma membrane and the nucleus
Where organelles are suspended
Nucleus:
Membrane-bound sac which contains the DNA
Contains DNA which contains instructions for building proteins
Has 2 functions:
a. Separate DNA from the rest of the cell parts
b. Outer membrane regulates passage of materials
Parts of the Nucleus:
1. Nuclear Envelope:
Consists of 2 lipid bilayers
Has pores (nuclear pores)
Controls passage of substances in and out of the nucleus
2. Nucleolus:
Contains a dense cluster of RNA and proteins
Construction site wherein ribosomal subunits are made
3. Nucleoplasm:
Fluid interior of the nucleus
4. DNA:
Chromatin is the cell's collection of DNA
Chromosome is a single DNA molecule with its proteins
Robert Hooke discovered cork cells, which he called "cellulae" meaning small rooms
Anton van Leeuwenhoek is known as the Father of Microbiology and developed Leeuwenhoek's Microscope
René Joachim Henri Dutrochet:
French physician and botanist
One of the first to conclude that various parts of organisms are made up of cells
Discovered osmosis
Robert Brown:
Observed Brownian movement
Noted that cells contain a large central part or nucleus, which he called "little nut"
Félix Dujardin:
French zoologist
Reported that cells are not hollow, empty structures but are full of a clear, jellylike fluid called cytoplasm
Matthias Schleiden:
German botanist
Stated that "All plants are made of cells"
Theodore Schwann:
German zoologist
Stated that "All animals are made up of cells"
Rudolf Virchow:
German physician
Coined the phrase "Omnis cellula e cellula" meaning "All cells come from pre-existing cells"
James Watson and Francis Crick:
Watson is an American biologist, Crick is a British biophysicist
Discovered the double helix structure of DNA
Rosalind Franklin and Maurice Wilkins:
British biophysicists
Produced images of DNA using x-ray diffraction, indicating the helical shape of DNA
Their photographs were used by Watson and Crick to determine the detailed structure of DNA
Jan Evangelista Purkyne, also known as Purkinje:
Discovered blood plasma and protoplasm
First to use a microtome
Prokaryotic Cell
Parts of a Prokaryotic Cell:
Capsule:
* Present in most pathogenic bacteria
* For protection
Cell Wall:
* Supports the cell and imparts shape
Plasma Membrane:
* Permeable to dissolved substances
Cytoplasm:
* Tiny volume
* Contains ribosomes
Nucleoid:
* Region which contains the bacterial DNA
Flagella/Cilia:
* For locomotion
Eukaryotic Cell
Common Parts of a Eukaryotic Cell:
Organelles:
* Internal, membrane-bound sacs
* Functions:
1. Compartmentalization
2. Allow interconnected reactions to proceed at different times
Organelles:
Rough Endoplasmic Reticulum
Smooth Endoplasmic Reticulum
Endoplasmic Reticulum:
A. Rough ER (RER):
* Continuous with the nuclear envelope
* Stack of flattened sacs
* Contains ribosomes, which synthesize proteins
B. Smooth ER (SER):
* Free of ribosomes
* Curved like pipes
* For lipid assembly
* Packaging center
* Modifies, sorts and packages materials in vesicles for export or for cell use
* Golgi Bodies
Types of Golgi Bodies:
1. Lysosomes:
Organelles of internal digestion
'Suicidal bag' of the cell
2. Peroxisomes:
Breakdown fat and amino acids
Vacuoles
Mitochondria:
* Powerhouse of the cell: forms ATP
* Contains an inner membrane, which is highly convoluted forming infoldings called cristae
Cytomembrane System
galileo galilei - insects eye
CELL CYCLE - the sequence of activities in cells during their development involving alternate division and ‘resting stage’
INTERPHASE ⚫ Cells are said to be ‘inactive’ or ‘resting’ ⚫ Undividing ⚫ stage A period of diverse activities ⚫ Cells synthesize RNA, proteins and grow in size ⚫ In mammalian cells, it lasts 12 24 hours
INTERPHASE - Cells are said to be ‘inactive’ or ‘resting’ ⚫ Undividing ⚫ stage A period of diverse activities ⚫ Cells synthesize RNA, proteins and grow in size ⚫ In mammalian cells, it lasts 12 24 hours