Prostaglandins and Oxytocic Drugs

• Medical Abortion = Mifepristone then misoprostol
• Surgical Abortion = Mifepristone or Gemeprost (2nd trimester)
• Mifepristone?

  MOA: Competitive progesterone receptor antagonist

  Indications: Termination up to 24 weeks

  SE: Uterine pain
• Misoprostol?

  MOA: Prostaglandin E1 analogue

  Indications: Manage miscarriage in Foetal Death

  Administration: Vaginal
• Gemeprost?

  MOA: Prostaglandin E1 analogue

  Indications: Soften cervix in induction and induce abortion

  SE: Uterine pain and coronary spasm
• Dinoprostone?

  MOA: Prostaglandin E2 analogue

  Indication: Induction of labour, stimulates contraction

  Administration: vaginal

  SE: Bronchospasm, uterine hypertonus
• Oxytocin?

  MOA: Increase Ca release from stores

  Indications: induction or augmentation of labour

  SE: need to ensure not too much
• Ergometrine?

  MOA: Uterine and vascular smooth muscle contraction

  Indication: PPH with uterine atony

  Admin: IM