MYCO Q3

• infections of subcutaneous mycoses involve which part of the skin?

  deeper skin layers: connective tissue, muscle, bone
• subcutaneous mycoses is a result from?

  traumatic puncture
• • clinical manifestations :progressive, non-healing ulcers draining sinus tracts ulcerated & crusted verrucous nodules - sclerotic bodies
• 4 types of subcutaneous mycoses?


  Chromoblastomycosis, Eumycotic Mycetomas, Phaeohyphomycosis, Sporotrichosis
• T/F: dissemination through blood to major organs occur with subcutaneous mycoses?

  False
• Caused by fungi and results in draining sinus tracts and tissue destruction?

  Eumycotic mycetoma
• tightly bound hyphae collected from fluids drained in sinus tract, useful in causative agent identification?

  grains (granules)
• 40% of mycetomas are? the rest are?

  eumycotic; actinomycotic
• Sporotrichosis is caused by?

  Sporothrix schenckii species
• How does sporotrichosis begins?

  single draining lesions -> limbs via lymphatic system
• T/F: granules are not formed in Eumycotic mycetoma that's why they are not qualified as mycetoma infections?


  True
• Sporotrichosis is caused by?

  Sporothrix schenckii species
• Causative agents of Chromoblastomycosis?

  Fonsecaea compactum, pedrosoi ; Phialophora verrucosa ;Cladophialophora carrionii ; Rhinocladiella aquaspersa
• Other name for Chromoblastomycosis?

  Verrucous Dermatitidis, Chromomycosis
• chronic mycosis of the skin and subcutaneous tissues

  Chromoblastomycosis
• confined to the extremities due to trauma

  Chromoblastomycosis
• ulcerated, crusty, cauliflower-like lesions

  Chromoblastomycosis
• brown, round, sclerotic bodies in tissues (Copper Penny Bodies)

  Chromoblastomycosis
• one-celled conidia formed on sympodial conidiophores

  Fonsecaea pedrosoi
• Primary conidia function as conidiogenous cells to form secondary one-celled conidia

  Fonsecaea pedrosoi
• Conidia are similar to Cladosporium sp. and Phialophora sp.

  Fonsecaea pedrosoi
• Similar to F. pedrosoi but compact conidial heads

  Fonsecaea compactum
• Fonsecaea compactum are _ rather than ovoid

  subglobose
• flask-shaped phialides with collarettes, conidiogenous cells, phaeoid

  Phialophora verrucosa
• Oval conidia, one-celled, occur in balls at tips of phialides

  Phialophora verrucosa
• erect conidiophores bearing branched chains of one-celled, brown blastoconidia

  Cladophialophora carrionii
• shield cell: conidium close to the tip of the conidiophore

  Cladophialophora carrionii
• erect conidiophore, dark, conidia ONLY on upper portion near the tip

  Rhinocladiella aquaspera
• Condia is elliptic, one-celled, produced sympodially

  Rhinocladiella aquaspera
• T/F: Eumycotic Mycetoma is caused by both fungi and bacteria (Actinomycotic mycetoma)

  True
• swelling, draining sinus tracts, + tissue destruction

  Eumycotic mycetoma
• presence of granules (tightly bound hyphae from drained fluids)

  Eumycotic mycetoma
• Causative agents of Eumycotic mycetoma?

  1. Pseudalleschria boydii
  2. Acremonium falciforme
  3. Madurella mycetomatis, grisea
  4. Exophiala spp.
• Pseudallascheria boydii anamorphic form:

  Scedosporium boydii
• oval conidia at the tips of conidiogenous cells

  Scedosporium boydii
• Pseudallascheria boydii teleomorph form:

  Cleisothecia (containing spores)
• slightly curved conidia (single/two-celled), hyaline

  Acremonium falciforme
• on tips of long, unbranched, multiseptated conidiophores

  Acremonium falciforme
• phaeoid, septate; conidia at the tips of the phialides

  Madurella mycetomatis & Madurrella grisea
• optimum growth temp: 37

  Madurella mycetomatis