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4. Psychopathology
4.6 The Biological Approach to Explaining OCD
4.6.1 Genetic Explanations
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What are the two main characteristics of Obsessive-Compulsive Disorder (OCD)?
Obsessive thoughts and compulsive behaviours
Compulsive behaviours are performed to reduce anxiety caused by
obsessions
Obsessive thoughts are voluntary ideas or impulses that individuals choose to have.
False
What is the purpose of compulsive behaviours in OCD?
Reduce anxiety
The COMT gene is involved in the regulation of
dopamine
The SERT gene regulates
serotonin
reuptake, which affects mood and anxiety.
Match the gene with its role in OCD:
COMT ↔️ Dopamine regulation
SERT ↔️ Serotonin reuptake
Twin studies compare concordance rates in identical and
fraternal
twins.
What percentage of genes do identical twins share?
100%
Higher concordance rates in identical twins suggest that genetic factors play a role in
OCD
.
Match the twin type with their genetic sharing:
Identical (Monozygotic) ↔️ 100%
Fraternal (Dizygotic) ↔️ 50%
What do twin and family studies suggest about the genetic basis of OCD?
Genetic factors play a role
The biological approach to OCD suggests that genetic factors play a significant role.
genetic
Twin and family studies indicate a higher concordance rate among identical twins for
OCD
.
The COMT gene is involved in dopamine regulation, which affects cognitive processes.
cognitive
The SERT gene regulates
serotonin
reuptake, impacting mood and anxiety.
What are the two main components of the definition of OCD?
Obsessive thoughts and compulsions
Key genes linked to OCD include COMT and
SERT
The COMT gene's role in OCD is
dopamine
regulation, affecting cognitive processes.
Higher concordance rates in identical twins for OCD suggest a significant
genetic influence
.
What percentage of genes do fraternal twins share?
50%
SLC1A1 genes are involved in neurotransmitter transport, specifically glutamate
reuptake
NRXN1 genes are essential for synaptic development and
impulse
control.
What do twin studies show about OCD heritability?
Higher concordance rates
Environmental factors can influence gene
expression
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