Clopidogrel

• What are the contraindications of clopidogrel?

  Bleeding disorder (e.g. haemophilia)

  Anyone recovering from recent surgery or trauma
• What are the indications of clopidogrel?

  Prevention of atherothrombotic events

  TIA
• What are the side effects of clopidogrel?

  Haemorrhage

  Diarrhoea

  Nausea
• What is clopidogrel?

  Antiplatelet
• What is the pharmacology of clopidogrel?

  Target: P2Y12

  Activity: Antagonist
• MOA - clopidogrel

  Irreversibly binds to P2Y12 receptors on platelets -> prevents ADP from binding to P2Y12 receptors -> prevents activation of glycoprotein GP IIb/IIIa complex -> prevents platelet aggregation