Atenolol

• What is atenolol?

  Selective b1 blocker
• What is the pharmacology of atenolol?

  Target: b1 receptor

  Activity: Competitive antagonist
• What are the indications of atenolol?

  Essential HTN

  Angina

  Arrhythmias
• What are the side effects of atenolol?

  Abdominal pain

  Diarrhoea

  Nausea
• MOA - atenolol

  Binds to & inhibits b1 adrenergic receptor ->

  • decrease CO
  • alter baroreceptor reflexes
  • decrease renin secretion
  • decrease sympathetic outflow

  = decrease HR