Although drugs such as SSRIs help most people, a small minority will get no benefit. Some people also experience side-effects such as indigestion, blurred vision and loss of sex drive. These side-effects are usually temporary, however they can be quite distressing for people and for a minority they are long-lasting. For those taking the tricyclic clomipramine, side-effects are more common and can be more serious. For example more than 1 in 10 people experience erection problems and weight gain, 1 in 100 become aggressive and experience heart-related problems.