What are the three steps of platelet plug formation?
Platelet adhesion
Release reaction
Platelet aggregation
Platelet adhesion
platelets stick to exposed collagen fibers of the damaged endothelium
Release reaction
platelets extend projections and degranulate releasing thromboxane A2, serotonin, ADP - which lead to constriction of blood vessels, and activate other platelets.
Platelet Aggregation
platelets get sticky and form plug which get reinforced by fibrin threads during clotting process
function of Neutrophil
first to arrive
contains lysozyme, defensins and superoxidants
function of basophil
releases histamine and other inflammatory chemicals