Pharma

• ANY CHEMICAL OR SUBSTANCE THAT AFFECTS THE PHYSIOLOGIC PROCESSES OF A LIVING

  ORGANISM

  Drug
• CHEMICAL COMPOSITION AND MOLECULAR STRUCTURE

  Chemical Name
• ONE DRUG IN A CLASS OF SEVERAL DRUGS IS CHOSEN AS THE PREFERRED AGENT, EVEN THOUGH THE DRUGS DO NOT HAVE THE SAME ACTIVE INGREDIENT

  THERAPEUTIC EQUIVALENCE
• BIOSIMILARS COPY VERSION OF AN ALREADY AUTHORIZED BIOLOGICAL PRODUCT
• RIGHT GRANTED TO AN INVENTOR BY THE GOVERNMENT THAT PERMITS THE INVENTOR

  TO EXCLUDE OTHERS FROM MAKING, SELLING OR USING THE INVENTION FOR A TIME PERIOD

  PATENT
• BETTER FOR FEVER IBUPROFEN
• CHILDREN UNDER 6 MONTHS AND PREGNANT WOMEN SHOULD AVOID IBUPROFEN AND TAKE ACETAMINPHEN
• GROUPING OF DRUGS BASED ON THEIR SIMILAR PROPERTIES

  DRUG CLASSIFICATION
• FIRST DRUG IN A CLASS OF DRUGS

  PROTOTYPICAL DRUGS
• STUDY OF HOW VARIOUS DOSAGE FORMS INFLUENCE THE WAY IN WHICH THE DRUG AFFECTS THE BODY

  PHARMACEUTICS
• DOSAGE FORMS INFLUENCE THE WAY IN WHICH THE DRUG AFFECTS THE BODY
• DOSAGE FORM DETERMINES THE RATE AT WHICH DRUG DISSOLUTION OCCURS
• ENTERAL TABLETS CAPSULES ORAL SOLUABLE
• INEJCTABLES, SUSPENSIONS, POWDERS FOR RECONSTITUTION PARENTERAL
• AEROSOLS, OINTMENTS, CREAM TOPICAL
• RELY ON GASTRIC AND INTESTINAL ENZYMES AND PH ENVIRONMENTS

  ORAL FORMS
• FENTANYL TRANSDERMAL PATCHES FOR PAIN TOPICAL FORMS
• APPLIED DIRECTLY ON THE SURFACE OF THE SKIN, WORK SLOWLY. TOPICAL
• DOSAGE FORMS THAT ARE ADMINISTERED VIA INJECTION

  PARENTERAL
• USUALLY IN AQUEOUS OR OILY FORMS. PARENTERAL
• PH OF INJECTIONS MUST BE SIMILAR TO THAT OF THE BLOOD FOR THESE DRUGS TO ADMINISTERED SAFELY. PARENTERAL
• DEGREE FOR INTRAMUSCULAR 90
• DEGREE FOR SUBCU 45
• DEGREE FOR INTRAVENOUS 25
• DEGREE FOR INTRADERMAL 10 TO 15
• LIQUID FORMS ARE DISSOLVED AND ABSORBED FASTER THAN SOLID TABLET FORMS
• SMALLER THE SIZE OF THE PARTICLE THE FASTER IT IS DISSOLVED AND ABSORBED
• EXTENDED RELEASE FORMS – EXAMPLE: DIVALPROEX SODIUM (DEPAKOTE EXTENDED RELEASE TABLET)
• IMMEDIATE RELEASE FORMS – EXAMPLE: PARACETAMOL + IBUPROFEN (ALAXAN FR)
• ENTERIC COATING – EXAMPLE: DICLOFENAC E/C
• 4 FACTORS THAT AFFECT SOLUBILITY OF DRUGS: SABIHIN
• 17 YEARS PATENT LIFE
• STUDY OF WHAT THE BODY DOES TO THE DRUG

  PHARMACOKINETICS
• INVOLVES THE PROCESS OF ABSORPTION, DISTRIBUTION, METABOLISM, AND EXCRETION PHARMACOKINETICS
• PARENT DRUG – CHEMICAL FORMS OF A DRUG THAT IS ADMINISTERED BEFORE IT IS METABOLIZED BY THE BODY INTO ITS ACTIVE OR INACTIVE METABOLITES
• PRODRUG – PARENT DRUG THAT IS INACTIVE THEN METABOLIZED INTO PHARMACOLOGICALLY ACTIVE METABOLITES
• 4 PROCESS OF pharmacokinetics: SABIHIN
• MOVEMENT OF DRUG FROM ITS SITE OF ADMINISTRATION INTO THE BLOODSTREAM FOR DISTRIBUTION TO THE TISSUES

  ABSORPTION
• PENICILLIN IS A SUBCLASS WITHIN THE B-LACTAM ANTIBIOTICS
• KEY DRUGS

  PROTOTYPICAL DRUG