Androgens

• Testosterone?

  Indications: HRT for men with testosterone deficiency, malnutrition in both sexes and certain breast cancer

  Absorption: Enhanced by esterification to create hydrophobic compounds

  Usually in gel preparation
• Testosterone top side effects?

  Male: Increased prostate cancer risk

  Hypogonadal adolescents: short stature

  Females: Hirsutism and virilisation
• Danazol?

  MOA: Androgen derivative which causes inhibition of GnRH

  Indications: Managing endometriosis, menorrhagia and gynaecomastia

  SE: Epigastric pain
• Anabolic steroid examples?

  Nandrolone and Oxymethylone
• Cyproterone Acetate?

  MOA: Progesterone causing inhibition of LH

  Indications: Prostate carcinoma and hyper-androgenisation in females

  Very long hold life