Flavonoid-Phenol Glycosides

• Flavonoids/Flavonol

  ● Isolated as yellow pigments in plants

  ● Best known flavonoid

  ○ Rutin

  ○ Quercetrin

  ○ Hyperoside

  ○ Bioflavonoids

  ■ Hesperidin, hesperitin, diosmin, naringen .

  ● Rutin + Hesperidin = VITAMIN P
• A.Gingko

  ● Leaves of Ginkgo biloba,

  Gingkoaceae

  ● Use : Antiasthmatic and bronchodilator
• ALCOHOL GLYCOSIDES

  A.Salicin

  ● Salix purpurea / S. fragilis

  ● With anti cancer claim and antirheumatic properties. (1g dose).

  ● Hydrolyzed into D glucose and aligenin (salicyl alcohol) by emulsin

  ● Populin - derivative (benzylsalicin)

  ○ Not a natural glycoside
• ALDEHYDE GLYCOSIDE

  ● Vanilla is a drug that has an aldehydic aglycone as

  its chief constituent.

  ● Vanillin is the aglycone developed during the

  curing of vanilla. Vanillin is methylprotocathechuic

  aldehyde
• A.Vanilla/Vanilla Bean

  ● Mexican - Vanilla plantifolia

  ● Tahiti - Vanilla tahetensis

  ● Green vanilla contains two glycosides, glucovanillin and glucovanillic alcohol

  ○ Glucovanillin - hydrolyzed during curing process

  into glucose and Vanillin

  ○ Glucovanillic alcohol - hydrolized into glucose

  and vanillic alcohol, which is oxidized to vanillic

  aldehyde (Vanillin)

  ● Vanillin - principal flavoring constituent
• LACTONE GLYCOSIDES

  Are benzopyrone derivative having aromatic smell and their aromatic solution when made alkaline shows blue or green fluorescence.
• A.Coumarin

  ● Use: flavoring agent

  ● Bishydroxycoumarin - is a drug related to coumarin , from the leaves of Melilotus officinalis . This drug is an anticoagulant
• B. Psoralens

  ● Methoxsalen , 8 methoxypsoralen, or

  xanthotoxin - a constituent of

  cremocarps , which is used to

  facilitate repigmentation in

  idiopathic vitiligo (leukoderma) and for symptomatic control of

  severe, disabling psoriasis