Antimetabolites

• Antimetabolites are cell cycles specific
• Antimetabolites act on S-phase
• Antifolates:

  1. methotrexate
  2. pemetrexed
  3. pralatrexate
• folic acid is essential for synthesis of purines and thymidylate
• Pyrimidine antagonists:

  1. 5-fluorouracil
  2. capecitabine
  3. cytarabine
  4. gemcitabine
• Purine antagonists:

  1. mercaptopurine
  2. thioguanine
  3. azathioprine
  4. fludarabine