Released from: Neurons of the spinal cord, cerebellum, basal ganglia, and many areas of cerebral cortex
Functions: Reduces neuronal excitability throughout the nervous system, acts as a brake to excitatory neurotransmitters, closely related to mood and emotions
Histamine:
Type: Excitatory
Released from: Hypothalamus, cells of the stomach mucosa, and a type of white blood cell in the blood
Functions: Regulates wakefulness, blood pressure, pain, sexual behavior, mediates inflammatory reactions, and increases acidity in the stomach
Glutamate (Glu):
Type: Excitatory
Released from: Sensory neurons and cerebral cortex
Functions: Regulates central nervous system excitability, learning process, and memory
Serotonin (5-HT):
Type: Inhibitory
Released from: Neurons of the brainstem, gastrointestinal tract, and thrombocytes
Functions: Regulates body temperature, perception of pain, emotions, and sleep cycle
Dopamine:
Type: Both excitatory and inhibitory
Released from: Substantia Nigra
Functions: Inhibits unnecessary movement, inhibits release of prolactin, stimulates secretion of growth hormone
Acetylcholine (Ach):
Type: Excitatory in all cases (except in the heart acts as inhibitory neurotransmitter)
Released from: Motor neurons, basal ganglia, postganglionic neurons of PNS, preganglionic neurons of autonomic nervous system, and postganglionic neurons of the sympathetic nervous system that innervates sweat glands
Functions: Very important for muscle function and movement, regulates sleep cycles
Norepinephrine (NE):
Type: Excitatory
Released from: Brainstem, hypothalamus, and adrenal glands
Functions: Increases the level of alertness and wakefulness, stimulates various other processes in the body
Epinephrine (Epi) also known as Adrenaline (Ad):
Type: Excitatory
Released from: Cells in the medulla of the adrenal gland
Functions: Triggers the fight or flight response, increases heart rate, blood pressure, and glucose production
Melatonin:
Type: Hormone
Released from: The pineal gland in the brain
Functions: Regulates the circadian rhythm, energy metabolism, the immune system, and is involved in the aging process
Endorphins:
Type: Hormone
Released from: Pituitary gland
Functions: Inhibits response to pain, muscle cramps, and is involved in relieving stress
Oxytocin:
Type: Hormone
Released from: Hypothalamus makes oxytocin, posterior pituitary gland stores and releases it in the bloodstream
Functions: Involved in social bonding, sexual arousal, romantic attachment, childbirth, parent-infant bonding, important for contractions during childbirth and lactation
Vasopressin:
Type: Hormone (antidiuretic hormone)
Released from: Regulates water balance in the body, synthesized in hypothalamus, released from posterior pituitary gland
Nitric Oxide:
Type: Gas
Released from: A variety of cells in the brain
Functions: Involved in brain blood flow (vasodilatation) and neurotransmission