Hormone therapy (Female)

• Selective Estrogen Receptor Modulator (SERM):

  1. Tamoxifen
  2. Raloxifene
• Aromatase inhibitors (AI)

  1.steroidal inhibitors

  • exemestane

  2.Non-steroidal inhibitors

  • anastrozole
  • letrozole
• Estrogen is suspected carcinogen. It has strong evidence associates this hormone to:

  1. breast cancer
  2. endometrial cancer
  3. uterine cancer
• Women that begin menstruating early and start menopause late has a higher risk of cancer. Why?

  They produce more estrogen over their lifetimes, where estrogen is a suspected carcinogen.
• In breast cancer, patient will express estrogen receptor and progesterone receptor
• 75% of breast cancers -> ER positive