Htn

• GREATER THAN 20 WEEKS GESTATION 


  GESTATIONAL HTN
• Gestational HTN BUT W/ ALBUMINERIA


  PRE-ECLAMPSIA
• Pregnancy Htn drugs


  Methyldopa

  Nifedipine

  Lebatolol

  Hydralazine
• Drugs for hypertnsive emergency 


  Enalaprilat

  Diaxozide

  Na Nitroprusside
• Site of action of thiazides


  Distal convulated tubule
• Mx for nephrogenic diabetes insipidus

  Thiazide
• Spirinolactone or aldactone


  Mx of HF

  For Conn's Syndrome
• Active metabolite of spirinolactone

  Canrenone
• Most effective and 100x selective

  Eplenorone
• Aka high ceiling; most effective among all diuretics

  Loop
• Only loop diuretics does not contain sulfur

  Phenoxyacetate
• Reversed drug for hypertnsive crisis

  Loop diuretics
• Natriuretics (increase Na excretion) drugs

  Thiazides

  K-sparring

  Loop
• Produce too much aldosterone

  Aldosteronism
• A natriuretics that prevents K excretion: and mineral corticoid receptor

  K sparring
• Natriuretic that are C/I to Colestipol and Cholestyramine

  Thiazides
• Prototype Benzothiazide Sulfur containing

  HYDROCHLORTHIAZIDE
• Aquaretics ( inc. Water excretion) drugs

  Carbonic Acid anhydrase Inhibitor

  Osmotic agents
• 1st line mx for open-angle glaucoma;

  Weakest diuretics

  Carbonic acid anhydrase Inhibitor
• most useful mx of Nephrolithiasis,

  Found useful for catamenial seizures;

  acute mountain sickness

  Acetazolamide
• Carbonic acid anhydrase Inhibitor drugs

  Brinzolamide (Azopt) Acetazolamide (Diqmoz)

  Methazolamide (Neptazone)

  Dorzolamide + Timolol (Trusopt®)

  Cosopt®

  Dichlorphenamide
• Mx in increased Intracranial Pressure or Edema

  Osmotic agents
• Parenteral HTN emergency drugs

  Na nitroprussdie

  diazoxide

  Fenoldopam
• Most effective arteriolar vasodilator

  Minoxidil
• Vasodilators used with Furosemide

  Diazoxide

  Na Nitroprusside
• Vasodilator drug that is a Complex of iron, CN and nitroso .

  Also Photosensitive

  Na Nitroprusside
• Nonselective sympatholytic vasodilator agent that is used for Persistent pulmonary HTN in newborn.

  Tolazoline
• Ca channel blockers are metabolized by what enzyme?

  CYP3A4
• Aka Peptidyl Dipeptidase or Kinase II


  ACE
• exhibits pharmacodynamic interaction w/ the Thiazide Diuretics leading to reduced diuretic fx

  Enalapril
• ARB's block what receptors?

  AT1 receptors
• ARB that has no teratogenic fx


  Telmisartan (micardis)
• First marketed ARBs


  Losartan and Valsartan
• Clonidine withdrawal is associated with what condition?


  Rebound hypertension
• Antidote for clonidine poisoning 


  NALOXONE
• It binds to a2- receptor at the presynaptic adrenergic neuron 


  Clonidine (Catapres)
• Analog of Levodopa 


  Methyldopa (Aldomet®)
• It is a false NT that is Converted to α methylnorepinephrine


  Methyldopa
• A test for hemolytic anemia


  Coomb's Test