Innate and adaptive immunity

• What are the primary lymphoid organs ?

  bone marrow and the thymus
• What are the secondary lymphoid organs?

  Lymph nodes, spleen and tonsils
• List key cells needed for the immune system

  granuloytes, monocytes and lymphocytes (B, T, T helper, cytotoxic T and NK cells
• First line of defence

  Skin and mucous
• Second line of defence

  Phagocytes, anti microbial proteins and inflammatory response
• Third line of defence

  Lymphocytes and antibodies
• Innate immune response properties:

  1st line of defence, non-antigen specific, no memory, better with adaptive immunity
• How does the innate immune system recognise microbes?

  Pattern recognition receptors
• • What are the types of pattern recognition receptors (PRRs)

  toll like receptors (TLR), nucleotide binding (NLR), C-type lectin (CLR) and RIG-1 (RLR)
• What do PRRs recognise On the microbes ?

  Microbe associated molecular patterns (MAMPS)
• What receptors mediate the innate response ? And what mediate the adaptive response?

  Innate- toll like receptors (TLR) and adaptive- antibody and T cell receptor
• Explain adaptive immunity

  Antigen specific and has a lag time. Enhanced effect by second exposure, has memory
• Memory T and B cells are rapidly

  Reactivated upon exposure to specific pathogens and coordinate a specific immune response