- As Desdemona sleeps in her room, Othello explains he will kill her, the he kisses her thus waking her.
- Desdemona weeps when Othello tells her that Cassio is dead and, believing Desdemona loved Cassio, Othello smothers her.
- Emilia is horrified when Desdemona revives briefly and says she caused her own death.
- After Othello explains why he killed Desdemona, Emilia insults him and summons Montano, Gratiano and Iago.
- Iago denies Emilia's accusations of villainy, stabs her and leaves her to die on the bed next to Desdemona.
- Guards return with Iago; Othello wounds him but Iago will not explain his actions.
- Iago's plots are revealed and, realising his folly, Othello kills himself.