MEKUS Y LIFE

• Prothrombin time (PT)

  Corrects

  • Factor deficiency (VIl, X, V, II)

  • Warfarin

  • Vitamin K deficiency

  • Liver disease

  Does not correct

  • Specific factor inhibitor (VII, X, V, II)

  • Direct Xa inhibitor
• Activated partial thromboplastin time (aPTT)

  Corrects

  • Factor deficiency (VII, IX, XI, contact factors)

  • Rarely, von Willebrand disease (if VIlI is low enough to prolong aPTT)

  Does not correct

  • Specific factor inhibitor (VIII, IX, XI, contact factors)

  • Heparin

  • Direct thrombin inhibitor,

  • Lupus anticoagulant
• PT and aPT

  Corrects

  • Common pathway factor deficiency (X, V, II)

  • Warfarin (high doses) or superwarfarin

  • Vitamin K deficiency

  • Disseminated intravascular coagulation

  • Liver disease

  Does not correct

  • Common pathway factor inhibitors (X, V, II)

  • Direct thrombin inhibitors

  • Direct Xa inhibitors

  • Lupus anticoagulant