BB-HISTORY

• A physician bled three young boys and had an ill Pope Innocent VIII drink the blood. Unfortunately, the boys and the Pope, died.


  1492
• Architect Sir Christopher Wren used a quill of a goose attached to a bladder to demonstrate that the intravenous injections of substances into animals had systemic effects.


  1656
• Dr. William Harvey’s “De Motu Cordis” paved the way for an entirely new arena of blood investigation. The book included a detailed information of the circulatory system.


  1628
• Dr. Richard Lower successfully transfused blood from one dog to another. This led Samuel Pepys to speculate potential benefits of human transfusion. “Bad blood” might be mended by “borrowing” blood “from a better body.”


  1666
• Dr. John Henry Leacock presented his dissertation “On the Transfusion of Blood in Extreme Cases of Haemorrhage”


  1816
• Dr. Richard Lower successfully transfused a Cambridge University student with sheep’s blood


  1667
• Dr. Denys performed transfusion

  To Antoine Mauroy, a madman using blood of a calf
• Dr. John Henry Leacock presented experiments that prove that transfusion can only be carried out by the same species
• First human to human transfusion had been performed by Dr. Philip Syng Physick


  1795
• First published animal-to-human transfusion performed by Dr. Jean Baptiste Denys on a 16 year old boy


  1667
• Dr. Denys performed transfusion


  Exchanging 3 ounces of boy’s blood for 9 ounces of a lamb’s blood
• Dr. Denys’ criticisms led to the ban of human transfusions in Europe (Paris Society of Physicians)
• Emil Ponfick observed red cell lysis in the blood of a woman who died after receiving transfusion of sheep’s blood


  Late 1800s
• Dr. Richard Weil suggested the inheritance of ABO types
• Dr. Karl Landsteiner discovered the ABO blood group


  1901
• Dr. James Blundell successfully transfused a woman dying from postpartum bleeding with blood from her husband


  1825
• Alfred Von Decastello and Adriano Sturli (Landsteiner’s former students) found the fourth blood type “AB”


  1902
• Dr. Richard Weil was the first to perform ABO typing and began compatibility testing


  1907
• Von Dungern described two different A antigens based on reactions between group A RBCs and anti-A and anti-A₁


  1911
• Dr. James Blundell invented the “Gravitator” and the “Impellor”
• Though many suggested that crossmatching was unnecessary if the selection of donors was restricted to individuals of the same blood group
• Philip Levine published a case report of post-transfusion hemolysis in a blood group O patient who received blood from her husband


  1939
• First Blood donor service was established by Percy Oliver, Secretary of the Camberwell Division of the British Red Cross


  1921
• Reuben Ottenberg demonstrated the importance of compatibility testing in his report of 128 cases of transfusion

  
  

  1913
• Felix Bernstein have successfully proven the inheritance pattern of blood groups


  1924
• First Blood donor service was established by Percy Oliver, Secretary of the Camberwell Division of the British Red Cross

  
  

  1921
• Sodium Citrate was discovered


  1914
• The American Association of Immunologists adopted a new classification scheme as proposed by Dr. Landsteiner, which is our current ABO terminology


  1927