Enzyme inhibition

• Competitive inhibitors are...

  1. Structurally similar to the substrate molecule
  2. Fits into the enzymes active site instead of the substrate molecule
  3. Prevents the substrate from binding
  4. Prevents the formation of enzyme-substrate complexes
• Increasing the substrate concentration with a competitive inhibitor will...

  Decrease the effect of the inhibitor as the enzyme is more likely to collide with a substrate
• Non-competitive inhibitors...

  1. They bind to the allosteric site of the enzymes
  2. This changes the overall shape of the enzyme molecule, and the shape of the active site
  3. The substrate will no longer fit into the active site
  4. Enzyme-substrate complexes cannot form
• Increasing the substrate concentration with a non-competitive inhibitor...

  Will not affect the rate of reaction