Diabetes & PAD

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Created by
Hiri P

Cards (3)

  • DM & PAD:
    • a 1% increase in Hb1Ac -> 28% risk of PAD
    • plus:
    • an increased rate of death
    • increased microvascular damage
    • increased risk of amputation
  • DM2/VAT causes Atherosclerosis:
    • DM2/VAT -> beta cell dysfunction -> hyperglycemia -> AGEs + endothelial damage -> atheroma -> atherosclerosis
    • DM2/VAT -> resistin -> FFAs -> converted into LDLs -> atheromas -> atherosclerosis
    • DM2/VAT -> inflammatory cytokines -> endothelial damage -> atheroma -> atherosclerosis
  • DM1:
    • beta cell dysfunction -> DM1 + hyperglycaemia
    • DM1 -> accelerated lipolysis -> FFAs -> converted into LDLs -> atheroma -> atherosclerosis
    • hyperglycaemia -> AGEs + endothelial damage -> atheroma -> atherosclerosis