1. Control disorders by altering the brain through surgery
2. Early attempt was the prefrontal lobotomy developed by Antônio Egas Moniz in 1935
3. Prefrontal lobotomy consists of cutting the connection to and from the frontal lobes, used to control violent, aggressive behavior
4. Psychosurgery today can be localized to very small areas of the brain, used rarely as it is irreversible
5. Severe obsessive-compulsive disorder