This is located in the renal cortex, right after the Bowman's capsule. It reabsorbs most of the filtered water, glucose, amino acids, and electrolytes back into the blood, helping the body retain important substances while starting the process of forming urine. This also secretes hydrogen ions (H⁺), creatinine, ammonia, and certain drugs or toxins into the tubule to help regulate blood pH and remove waste products.