Cardiac chest pain due to MI or angina if systolic BP is more than 90 mmHg
Acute heart failure with ischaemia and uncontrolled hypertension
Patients with a suspected cocaine overdose presenting with chest pain
Efficacy - the ability of a drug to produce a desired effect
pharmacokinetics - the study of the body interaciton with a drug
pharmacodynamics - the study of how a drug affects the body
Drug affinity - the extent to which a drug binds to receptors at any given drug concentration or the firmness with which the drug binds to the receptor
Receptor - A specialised target macromolecule that binds a drug and mediates its pharmalogical action
Antagonist - A substance that stops the action of effect of another substance
chronotope - a drug that effects heart rate
agonist - a drug that binds to a receptor inside a cell or on its surface and causes the same action as the substance that usually binds
Partial agonist - binds to an active receptor, but are not able to elicit maximum possible response
adrenoreceptors - mediate the central and peripheral actions of the neurotransmitters adrenaline and noradrenaline
cholinoceptors - receptors which respond to the transmitter acetylcholine and are mostly parasympathetic
half-life - the time it takes for the amount og drugs active substance in your body to reduce by half
first pass metabolism - medication undergoes metabolism at a specific location in the body. this decreases the active drugs concentration upon reentering systemic circulation