Salmeterol

• What is salmeterol?

  LABA

  Long-acting beta agonist
• What are the indications of salmeterol?

  Asthma

  COPD
• What are the side effects of salmeterol?

  Palpitations

  Tremor

  Headache
• What is the pharmacology of salmeterol?

  Target: b2 adrenoreceptor

  Activity: Agonist
• MOA - salmeterol

  Salmeterol binds to b2 adrenoreceptors -> activation of adenyl cyclase -> increased intracellular conc of cAMP -> activation of protein kinase A -> inhibits phosphorylation of myosin & lowers intracellular Ca+2 conc -> smooth muscle relaxation

  = bronchodilation & increased airflow