Omalizumab

• What is omalizumab?

  Monoclonal antibody
• What is the pharmacology of omalizumab?

  Target: IgE

  Action: Antagonist
• What are the indications of omalizumab?

  Asthma
• What are the side effects of omalizumab?

  Headache

  Skin reactions

  Diarrhoea
• MOA - omalizumab

  Inhibits binding of IgE to FcεRI on surface of mast cells & eosinophils -> release of inflammatory cytokines (IL-4, IL-5, IL-13) -> decreased allergic response