Mepolizumab

• What is mepolizumab?

  Monoclonal antibody
• What are the indications of mepolizumab?

  Asthma (eosinophilic)
• What are the side effects of mepolizumab?

  Abdominal pain

  Eczema

  Fever
• What is the pharmacology of mepolizumab?

  Target: IL-5

  Activity: Antagonist
• MOA - mepolizumab

  IL-5 -> growth differentiation, recruitment, activation, survival of eosinophils

  Mepolizumab -> decreases IL-5 -> decreased eosinophils -> decreased eosinophilic response