W3L6 - DNA damage MCQ

• Which of the following are examples of how mutations in DNA can occur:

  1. Deletions (loss of nucleotide(s))
  2. Insertions (gain of nucleotide(s))
  3. Purine to purine - e.g. A to G
  4. Pyrimidine to pyrimidine - e.g. C to T
  5. Transversions - Purine to pyrimidine
  6. Transversions - Pyrimidine to purine

  all of the above
• Which of the following would cause exogenous damage to DNA?

  1. Chemicals (e.g. hydrocarbons in cigarette smoke)
  2. DNA replication errors
  3. Hydrolysis - water drives the reaction
  4. Ionising radiation (e.g. X rays)
  5. Oxidation
  6. UV (sunlight)

  1, 4, 6
• Endogenous damage to DNA is caused by.......

  1. Chemicals (e.g. hydrocarbons in cigarette smoke)
  2. DNA replication errors
  3. Hydrolysis - water drives the reaction
  4. Ionising radiation (e.g. X rays)
  5. Oxidation
  6. UV (sunlight)

  2, 3, 5